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KMID : 0379119990270030237
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Korean Journal of Mycology
1999 Volume.27 No. 3 p.237 ~ p.241
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Anti-Varicella Zoster Virus Activity of Water Soluble Components of Elfvingia applanata Alone and in Combinations with Interferons
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Abstract
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To search for less toxic antiviral agents from Basidiomycetes, the water soluble components (=EA), were isolated from the carpophores of Elfvingia applanata (Pers.) Karst. Anti-varicella zoster virus (Oka strain; anti-VZV/Oka) activity of EA was examined in MRC-5 cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha or IFN gamma were examined on the multiplication of VZV/Oka. EA exhibited a dose-dependent reduction in the plaque formation of VZV/Oka with 50% effective concentration (EC_(50)) of 464.14 ㎍/㎖. The results of the combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combination of EA with IFN alpha showed partially synergistic or additive effects with CI values of 0.83∼1.09 for 50%, 70%, 90% effective levels, and those with IFN gamma showed antagonism with CI values of 1.20∼1.24.
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KEYWORD
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